If you know of another definition of XTREME that should be included here, please let us know. You can sign in â¦ 23 Jan. 2021. 4. â¢ EXTREME (adjective) The adjective EXTREME has 4 senses:. Definitions.net. We truly appreciate your support. Being in or attaining the greatest or highest degree; very intense: extreme pleasure; extreme pain. Tremé; is a neighborhood of the city of New Orleans.
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